david jones, Amerigo Scientific

david jones, Amerigo Scientific 25 days ago

Major histocompatibility complex (MHC) class I and class II molecules share the task of presenting peptides on the cell surface for recognition by T cells and play a pivotal role in the adaptive immune system.

Peptide-MHC (pMHC) complexes are recognized by CD4+ and CD8+ T cells expressing a repertoire of hypervariable αβ T cell receptors (TCRs). The interaction between the pMHC complex and a cognate TCR is short lived and of low affinity. By the multimerization of four pMHC molecules on a streptavidin scaffold, the tetramer binds to TCR with high affinity and specificity. Thus, pMHC tetramers can be used to identify, monitor, and handle T cells through direct and specific staining.

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