Idea: Gene Therapy

Thomas Schmitt 20 days ago

Gene therapy has emerged as a promising approach to the treatment of genetic disorders and various diseases by introducing therapeutic genes into target cells. One critical aspect of gene therapy is the use of viral vectors to deliver these therapeutic genes effectively. However, the development and utilization of viral vectors in gene therapy require comprehensive characterization and quality control to ensure their safety, efficacy, and reproducibility.

As a leader in virology testing services, Creative Diagnostics offers a wide range of platform technologies, ready-to-use assays, and custom assays to support viral vector characterization and potency evaluation at various stages of development.

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Idea: HCP Antibody

Thomas Schmitt 20 days ago

Creative Diagnostics is a one-stop shop for manufacturing need for custom HCP antibodies. In addition to standard antibody development and production processes, the materials needed for development purposes and proof-of-concept studies will be provided. Risk mitigation of project at later stages can be executed by assessment of the developability of prospection antibody.

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Single Radial Immunodiffusion (SRID) Testing Service

Single radial immunodiffusion (SRID) is an agar gel precipitation test used to determine the quantity or concentration of an antigen in a sample. Antibody of known specificity is distributed evenly in an agar gel, and a sample containing the antigen of interest is placed in a well within the gel. Antigen then diffuses radially from the well, and a precipitin ring forms at the point of antibody-antigen equilibrium. Antigen concentrations are determined by measuring the diameter of precipitin rings and extrapolating using standard curves.

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Thomas Schmitt about 1 month ago

Eculizumab ELISA Kit

Enzyme immunoassay for the specific and quantitative determination of free Eculizumab (Soliris) in serum, plasma and cell culture samples.

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Thomas Schmitt about 1 month ago

Colistin ELISA Kit

The Colistin ELISA Kit is a competitive enzyme immunoassay for the quantitative analysis of colistin in meat (beef, pork and chicken) samples.

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Custom Virus Production Service

Save precious time for your research and avoid all tedious virus production steps. Creative Diagnostics provides you with customized virus production services. We cultivate, titrate, and purify numerous viruses from various species. Our service includes processing both BSL-2 and BSL-3 pathogens in certified bio-isolation laboratories, making wild-type and recombinant viruses, and preparing the nucleic acids probes.

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Hemagglutination Inhibition Assay (HAI) Hemagglutination inhibition (HI or HAI) is used to determine relative concentrations of viruses, bacteria, or antibodies invented by American virologist George Hearst in 1941. This experimental method utilizes surface proteins of various viruses (such as hemagglutinin (HA) of influenza virus) to agglutinate multiple types of red blood cells (RBC).

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Thomas Schmitt 3 months ago

Loading control antibodies Loading controls are frequently chosen from the proteins which are expressed by the ‘housekeeper genes'. These controls help normalize the levels of protein of interest by confirming that the total protein loading is the same across the gel. The expression levels of the loading control should be constant between the different sample lanes. It is also important that the protein chosen as a loading control should have a different molecular weight compared to the protein of interest, to avoid overlapping staining and interference to the result.

Creative Diagnostics offers highly specific antibodies to the most common targets: α- and β-Tubulin, COX IV, GAPDH, β-Actin, Histone H3.

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Cancer and Apoptosis

Apoptosis is a type of programmed cell death. With respect to cell necrosis, apoptosis is actively performed by cells. Apoptosis is generally induced by physiological or pathological factors, which in turn trigger a series of cellular changes. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay. And they lead to characteristic cell changes (morphology) and death. For common multicellular organisms, apoptosis is a normal physiological phenomenon. For example, the average adult human loses between 50 and 70 billion cells each day due to apoptosis; and human child between the ages of 8 and 14, approximately 20 to 30 billion cells die a day. Owing to apoptosis as a physiological process of a determinant of cell fate, its balance is of great importance to the body. For instance, excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. Therefore, apoptosis is rigorously regulated by suppressor and pro-apoptotic factors.

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